Case Report: Hyperprolactinemia and growth hormone deficiency associated with Morning Glory Syndrome; with a

Morning Glory Syndrome (MGS) is a rare congenital malformation of the optic nerve that is caused by a failure of the closure of the choroidal embryonic fissure . The syndrome is usually seen in association with midline in utero cranial defects, such as transsphenoidal and basal encephaloceles. Although MGS usually presents as an isolated ocular finding, it can be associated with endocrinological abnormalities. We report a case of a 32 year old female with MGS with hyperprolactinemia and growth hormone (GH) deficiency. She was diagnosed with MGS at the age of three and her past medical history was significant for left eye blindness, hyperprolactinemia and GH deficiency. She has received GH replacement and oral contraceptive pills in the past. Our investigations revealed elevated prolactin levels (63mg/l) and borderline low GH levels. Magnetic resonance imaging revealed an abnormality involving the optic chiasm, left optic nerve and compression of the pituitary gland by a basal encephalocele. Genetic studies were positive for a mutation in Paired box 6 gene ( . She is being currently treated with cabergoline for her PAX6) hyperprolactinemia. Our aims of this report are to highlight the hormonal manifestations of MGS and to review the etiopathogenesis of this rare disorder. Ravi Bhavsar ( ) Corresponding author: [email protected] : Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Project Administration, Resources, Author roles: Bhavsar R Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing; : Formal Analysis, Pavlovic M Investigation, Methodology, Software, Supervision, Writing – Original Draft Preparation, Writing – Review & Editing; : Formal Analysis, Razavi A Investigation, Resources, Software, Validation, Visualization, Writing – Review & Editing; : Investigation, Methodology, Project Umair M Administration, Software, Supervision, Validation, Visualization, Writing – Review & Editing; : Investigation, Project Administration, Senapathi H Resources, Software, Supervision, Validation, Visualization; : Conceptualization, Investigation, Supervision, Validation, Visualization, Sachmechi I Writing – Review & Editing Competing interests: No competing interests were disclosed. Bhavsar R, Pavlovic M, Razavi A How to cite this article: et al. Case Report: Hyperprolactinemia and growth hormone deficiency associated with Morning Glory Syndrome; with a review of the literature [version 1; referees: awaiting peer review] F1000Research 2017, :1702 (doi: ) 6 10.12688/f1000research.12655.1 © 2017 Bhavsar R . This is an open access article distributed under the terms of the , which Copyright: et al Creative Commons Attribution Licence permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The author(s) declared that no grants were involved in supporting this work. Grant information: 18 Sep 2017, :1702 (doi: ) First published: 6 10.12688/f1000research.12655.1 Referee Status: AWAITING PEER REVIEW 18 Sep 2017, :1702 (doi: ) First published: 6 10.12688/f1000research.12655.1 18 Sep 2017, :1702 (doi: ) Latest published: 6 10.12688/f1000research.12655.1 v1 Page 1 of 4 F1000Research 2017, 6:1702 Last updated: 18 SEP 2017